Abstract: Standard methods for multi-label text classification largely rely on encoder-only pre-trained language models, whereas encoder-decoder models have proven more effective in other classification tasks. In this study, we compare four methods for multi-label classification, two based on an encoder only, and two based on an encoder-decoder. We carry out experiments on four datasets---two in the legal domain and two in the biomedical domain, each with two levels of label granularity--- and always depart from the same pre-trained model, T5. Our results show that encoder-decoder methods outperform encoder-only methods, with a growing advantage on more complex datasets and labeling schemes of finer granularity. Using encoder-decoder models in a non-autoregressive fashion, in particular, yields the best performance overall, so we further study this approach through ablations to better understand its strengths.